The Uncover Study
The Uncover study is designed to test the safety and effectiveness of an investigation drug, ixekizumab, for moderate to severe plaque psoriasis.
You may qualify for the Uncover study if you:
Are 18 years of age or older (male or female)
Have been diagnosed with moderate to severe plaque psoriasis
Have not taken ENBREL® (etanercept) for your psoriasis
About the Investigational Medication
You will receive the investigational drug, ixekizumab, as an injection under the skin. Participants will receive either the investigational drug, an approved biologic medication commonly prescribed to treat psoriasis (etanercept), or placebo (similar in appearance to the investigation drug but has no medicine). This is a double-blind study which means that neither you nor the study doctor will know which study medication you will be provided. However, in the event of an emergency, this information will be available.
About Participating in the Uncover Study
If you decide to participate in this psoriasis clinical trial, you will be one of approximately 3,750 men and women taking part in this study around the world. Your participation will last for approximately 1 year with a 4-5 year extension period immediately following, so that study doctors can continue to monitor your condition.
The study staff will evaluate whether there is any improvement in your skin affected by psoriasis. During the study, the study staff will measure the extent and severity of your psoriasis to check to see if the investigational drug is helping to improve your plaque psoriasis symptoms.
You will be asked to come to the study center for regular study visits. During the first month of the study, study visits will be scheduled between one and two weeks apart. After this period, study visits are less frequent. You can expect monthly visits, followed by quarterly study visits during the extension period.
If you choose to participate, you may leave Uncover at any time and for any reason. You do not have to participate in Uncover. There are treatment options available for psoriasis that you can discuss with your doctor.
Benefits of Participating
Clinical research studies play an important role in the development of future, new and better treatments for all conditions, including plaque psoriasis.
You may wish to participate in the Uncover study for the following reasons:
If you qualify for this clinical research study, all study-related medical care and the investigational drug will be provided to you at no cost.
Satisfaction of helping researchers to learn more about the investigational drug, which may help researchers and contribute to treatments in the future that could help individuals with plaque psoriasis.
To sign up for a plaque psoriasis study and talk to a study coordinator, please fill out the Sign Up for a Study form or call Advanced Clinical Care at 508-755-0201.