Status: Enrolling Principal Investigator: Charles Birbara, M.D. Dr. Charles Birbara is a practicing rheumatologist in Worcester, MA. He is a graduate of Harvard College and received his medical degree from McGill University and completed his rheumatology fellowship at Northwestern University in Chicago. He is currently an Associate Professor of Medicine at the University of Massachusetts Medical School. Dr. Birbara has been involved in clinical research trials since 1975 and has been the Medical Director of Advanced Clinical Care since 1989. Dr. Birbara has served as Principal Investigator for over 500 clinical research protocols, the majority of which have been in the areas of rheumatoid arthritis, osteoarthritis and pain. Dr. Birbara has authored or co-authored numerous manuscripts published peer reviewed journals. He is a fellow member of the American College of Rheumatology. Study Description: We are currently recruiting patients for a study testing the safety and efficacy of a new pain medication for people with osteoarthritis in the knee....